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During early growth (until about the second year after birth), about 1020% of the amino acid pool is used in growth and is thus not available for GSH synthesis and one-carbon metabolism [7577]

In a small-animal model of arthritis, zonulin acted as a disruptor of the tight junction barrier by reducing expression of occludin and ZO-1, associated with increased intestinal permeability to macromolecules (48)

Their review aimed to provide scientific evidence for this association, highlighting the role of gut microbiota in inflammatory processes related to OA [132]

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