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Intranuclear inclusions, neuronal loss and CAG mosaicism in two patients with Machado-Joseph disease

First, human amylin is aggregation-prone: at pharmaceutical concentrations it readily forms amyloid fibrils, the same class of deposits studied in the context of pancreatic islet pathology

Curcumin treatment reduces motor impairments and protects against rotenone-induced neurodegeneration in a rat model of Parkinson disease

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Document cycles, symptom changes, and lab results to judge progress