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To stabilize itself, it rapidly binds to another oxidized glutathione molecule, forming the disulfide compound GSSG

Bioorg Med Chem Lett (2006) 16(13):36147

Beyond that, methyl groups donated through the methylation cycle land on DNA itself, which is how the body controls gene expression turning genes on and turning genes off

Protection against Chemotherapy-Induced Toxicity: Chemotherapy is a common treatment for cancer, but it often causes significant side effects

These findings position the compound as a valuable research tool for investigating whether NNMT modulation influences age-associated metabolic changes in mammalian aging models