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It usually means either the root cause needs further investigation (which is where functional lab testing becomes valuable) or the protocol needs adjustment

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Changes in evening melatonin or its urinary metabolite were reported in selected aged-animal and low-melatonin research groups

The through-line in all of these is a familiar mechanism of hype: a real but limited laboratory observation is amplified, stripped of its qualifiers, sometimes attributed to the wrong molecule (AHK-Cu results claimed for GHK-Cu), and then presented with a precise-sounding statistic that implies clinical certainty

For others, the odd drink is unlikely to cause trouble