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However, AOD-9604 is listed on the WADA Prohibited List and must not be used by athletes

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In scientific literature, NNMT is recognized as an enzyme that methylates nicotinamide (a precursor of NAD+) using S-adenosylmethionine (SAM) as the methyl donor, converting it to 1-methylnicotinamide (MNA) and potentially affecting cellular NAD+ availability

Researchers observed that by blocking this enzymatic step, 5-Amino-1MQ may increase the availability of nicotinamide for conversion back to NAD+ through the salvage pathway