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Following single-dose administration of 30.58 or 61.48 mg HTY, peak plasma concentration was achieved at 30 min, with primary circulating metabolites being homovanillic acid, HTY-3-O-sulfate, and 3,4-dihydroxyphenylacetic acid detected in both plasma and urine, supporting the systemic absorption and metabolite formation observed in animal models [38]

doi: 10.1016/j.jff.2017.12.028

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