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Signaling by gasotransmitters

Full therapeutic benefit typically becomes evident within three to six months, with many patients experiencing sustained pain relief that persists long after the treatment course ends

Bifidobacterium can convert deoxycholic acid, a bile acid, into UDCA through hydroxy sterol dehydrogenase, replenishing the bodys own UDCA

Although dietary fiber has been associated with microbiome changes 75 , this is unlikely to account for the microbiome changes observed herein since fiber content was the same across diets