The study found that while overall BMD declined in both the treatment and placebo groups, those with lower baseline B12 status experienced a reduced rate of BMD decline with B-vitamin supplementation
Then, weekly for a few more weeks
Combined supplementation improves resistance to infections and supports faster recovery
Severity of Deficiency: Those with more severe deficiencies might need more shots or higher doses at first
doi: 10.3389/fphar.2025.1602976 Received 30 March 2025 Revised 13 November 2025 Accepted 14 November 2025 Published 19 December 2025 Volume 16 - 2025 Edited by Bernd Rosenkranz, Fundisa African Academy of Medicines Development, South Africa Reviewed by Kacper Nijakowski, Poznan University of Medical Sciences, Poland Miriam Njoki Karinja, Science for Africa Foundation, Kenya Updates Copyright 2025 Mazur, Ndokaj, Salerno, Vallone, Ardan, Bietolini, Carrouel, Wilk, Sarig, Ottolenghi and Bourgeois