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It was included as a tertiary agent in the 2017 edition of the multi-agency clinical guidelines for the treatment of hypertension (Whelton et al, 2018), but was no longer mentioned in the 2025 AHA/ACC multisociety hypertension guidelines (Jones et al, 2025)

Yendamuri S, Vaporciyan AA, Zaidi T, Fernandez R, Rice DC , Spitz M, Swisher S, Walsh GL, Roth JA, Katz RL

The honest answer about what they do, what the evidence says, and how we approach them at CoLaz

doi: 10.1016/j.molmet.2024.101944 53 WangD.PanY.ChenW.HeD.QiW.ChenJ.et al

No batch tracking or recall pathways If a contaminated vial causes an infection or systemic reaction, you may have no qualitycontrol paper trail