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Sciatica and Impingement When a disc bulges in your back and crushes the sciatic nerve, the damage is twofold: mechanical pressure and chemical inflammation

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Media Attributions Figure 11.1.1 Steven Earle, CC BY SA 4.0, after Water Cycle by Ingwik, CC BY SA 3.0, via Wikimedia Commons, Figure 11.1.2 Steven Earle, CC BY 4.0 Figure 11.1.3 Modified by Steven Earle, from Mackenzie River with Heavy Sediment Load by Pierre Markuse, 2018, CC BY 2.0 via Flickr,

In DFU, notch pathway dysfunction can lead to inhibition of cell differentiation, proliferation disorders, and reduced angiogenesis, all of which interfere with diabetic wound healing