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Potential side effects may include: Water retention Joint pain Numbness or tingling Insulin resistance Headaches Hormonal imbalances Injection site reactions More serious concerns include: Long-term cancer risk (due to IGF-1 stimulation) Endocrine disruption Unknown contamination in unregulated products Additionally, many peptides are banned by sports organizations, such as the World Anti-Doping Agency

These binding proteins would be expected to decrease the transfer of IGF-I, but not that of the variants, from blood to tissue sites of action

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