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Pradas, I

In endothelial cells, we observed that SMG exerted several detrimental effects, including elevated ROS production, mitochondrial membrane depolarization, oxidative DNA damage that triggered apoptotic pathways, as well as the upregulation of angiogenic and oxidative stress genes, such as VEGFA, HIF-1, eNOS, and iNOS

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Sun, Y., Zheng, Y., Wang, C., and Liu, Y., Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells