Bisulfite sequencing PCR To assess the impact of VCD and supplemental vitamin B12 on the methylation levels of 17 CpG sites located in the promoter region and proximal portion of the first exon of CCL11 , DNA libraries obtained from cultures of endpoints A and B were analyzed using Bisulfite Sequencing PCR (BSP)
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Phase 2 Side-Effect Frequencies at 4.5 mg/week (Lancet 2021) Side Effect Nausea Incidence at 4.5 mg/week 47% Side Effect Injection-site reactions Incidence at 4.5 mg/week 43% Side Effect Constipation Incidence at 4.5 mg/week 21% Side Effect Fatigue Incidence at 4.5 mg/week 20% Side Effect Allergic reactions (any) Incidence at 4.5 mg/week 10% Side Effect Vomiting Incidence at 4.5 mg/week 8% Side Effect Loose stools Incidence at 4.5 mg/week 7% Side Effect Headache Incidence at 4.5 mg/week 7% Side Effect Indigestion Incidence at 4.5 mg/week 4% Incidence was lower at lower doses
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Gastrointestinal Research BPC-157 was originally identified as an anti-ulcer agent, and the gastrointestinal literature remains central