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Melatonin exerts protective effects in an ILC2-biased model of allergic airways disease, even in the presence of canonical receptor blockade To determine whether the protective effects of melatonin extended beyond allergen-driven disease, we next employed an ILC2-biased IL-33 model of allergic airways inflammation ( Figure 2A )

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To further distinguish heterogeneous conformations observed in the datasets of CTR:Cagri/CagriBB, the authentic particles of complexes were separated into multiple clusters by 3D Classification in cryoSPARC with approximately 50100k particles for each cluster