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In addition, both riboflavin and PLP are essential determinants of the kynurenine pathway which influence glutamate receptors, hence, glutamate excitotoxicity potential, as shown in Section Riboflavin as a Determinant of the Kynurenine Pathway. Concerning PD, glutamate excitotoxicity contributes to dopaminergic neuronal loss (84)

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2.2.3 Nephroprotective A correlation of improved renal outcomes was demonstrated in a systematic review of 8 RCTs with 39,040 T2DM patients [39]