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23,613,614 It is worth noting that clinical trials of NAM have been initiated in patients with cancers including bladder cancer, non-small-cell lung carcinoma, non-melanoma skin cancer, non-Hodgkins lymphoma and multiple myeloma (Table 1)

10.1159/000113760 59 FllerM.FeilS.GhoreschiK.KokaS.GerlingA.ThunemannM.et al (2008a)

K., Devaraj, S., Yuhanna, I., Shaul, P

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Concretely, lactylation of PDHA1 at K336 and CPT2 at K457/8 results in the inactivation of both enzymes and the inhibition of OXPHOS by restricting acetyl-CoA influx from pyruvate and fatty acid oxidation, respectively