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Through a systematic review, we identified that oxidative stress played a significant role in the pathogenesis of OA, and metformin had potential antioxidative capacity in relieving various chronic inflammation-related diseases, raising the possibility of treating OA

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In the livers of ALC-treated mice, cholesterol metabolism-related genes exhibited changes, with significant decreases in SREBP2 and HMGCR, key components of the cholesterol synthesis pathway

10.1007/s10815-022-02429-9 94 OharaM.Yoshida-KomiyaH.Ono-OkutsuM.Yamaguchi-ItoA.TakahashiT.FujimoriK