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Lipid Metabolism and Body Composition Endpoints of interest include changes in visceral and subcutaneous adipose tissue, hepatic lipid content, and circulating lipids

The critical characteristics of ferroptosis are marked by iron accumulation and lipid peroxidation

We identified that Glutathione Peroxidase 3 (GPx3), a critical plasma-based antioxidant enzyme, was the sole protein examined that was both significantly and differentially abundant between affected and non-affected participants in both cohorts, with large reductions observed in those affected with konzo

In order to correctly identify mutations previously published, the following changes should be kept in mind: the variable polyglutamine tract length is two longer (23 instead of 21), whereas the variable polyglycine tract length is one shorter (23 instead of 24) for NM_000044.3 versus M20132.1, respectively

N-Acetyl-Cysteine (NAC)is a source of the conditionally essential amino acid L-cysteine and a precursor to the tripeptide glutathione