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A significant association between CD14+ Monocyte-like scores with M4 (n = 37 patients) and M5 (n = 21 patients) French-American British classifications (FAB) AML, and granulocyte-monocyte progenitor GMP-like scores with Core Binding Factor (CBF) fusions (n = 13 patients)

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Preclinical studies have demonstrated that PT2385 leads to marked tumor regression in VHL-deficient RCC, supporting its selective efficacy (187)

Since they work through different mechanisms, many people choose to include both in their routine