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Zhou T, Ahmad TK, Gozda K, Truong J, Kong J, Namaka M

Individuals with psoriasis have been shown to have lower concentrations of selenium compared to healthy individuals without a history of psoriasis

The ligands for PD-1, namely PD-L1 and PD-L2 (members of the B7 family), are expressed on tumor cells and MDSCs [107], tumor-associated macrophages (TAMs), and M2 macrophages [22]

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Our data show auto-AcT activity is used by SnCE1 to regulate important protein functions, i.e., affecting autoproteolytic processing needed for efficient cytosolic and mitochondrial distribution in the host cell and to stabilize the SnCE1 monomer, thereby improving its deSUMOylase activity as structurally tetramer formation and SUMO binding at the S1 site are mutually exclusive