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ACTH-mediated cortisol synthesis from the zona fasciculata cells depends on a large number of factors of the adrenal microenvironment, such as chromaffin and immune cells, adipocytes, and adrenal innervation

Excretion is presumed to occur primarily through renal and hepatic routes, based on typical peptide pharmacokinetics

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The case for the injectable route over oral comes down to one thing: bioavailability

Wiley-Blackwell, Chichester Anselmo AC, Mitragotri S (2016) Nanoparticles in the clinic