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There is only the case of the nuclear transcription factor c-Jun that, due to an unusual redox potential, could react with GSSG at relatively high ratio of GSH/GSSG = 13 (Klatt et al., 1999)

A., & Kanakis, C

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The reaction mixture (DHA) contained 90 mM potassium buffer with phosphate (pH 7.0), 12.5 mM glutathione reductase (GSH), 0.178 mM EDTA, 0.1 mM enzymes extract, and 1 mM dehydroascorbate