Highlight compounds 20 25 proved to be potential XO and/or COX inhibitors in vitro, with the most potent XO inhibitor exhibiting an IC 50 value of 9 nM, being more potent than febuxostat (26 nM), used as a standard (Table 1)
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Cell and tissue research, 377 (2), 153159
However, both genome-wide association studies (GWASs) and candidate gene studies have confirmed an important role for human leukocyte antigen (HLA) class I and class II genes in some but not all forms of DILI