melanotic macule in mouth Pigmented Oral Lesions: Clues to Identifying the Potentially Malignant Melanotic macules of the tongue

While agents like DFP and NAC demonstrate favorable BBB penetration, their systemic effects on iron metabolism raise concerns: iron chelators can induce unintended iron deficiency in peripheral tissues, while antioxidants may disrupt physiological redox balance, highlighting the need for brain-targeted delivery to minimize off-target effects

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Specific occlusion syndrome induction can be performed by the occlusion of a major vein (Vukojevic et al., 2018

doi: 10.1016/j.bbadis.2020.166037 194

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