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Figure 1 Animals and Treatment Six-week-old male C57BL/6J mice were obtained from Shanghai Slake Experimental Animal Co., Ltd

IV protocols: 6002,000 mg per session, 12 times weekly

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5.2.2 Regulation of insulin resistance: pioglitazone Pioglitazone, a classic PPAR agonist, improves insulin sensitivity and alleviates systemic lipotoxicity by promoting adipocyte differentiation, enhancing adiponectin secretion, and reducing the expression of TNF - and MCP-1 (148)