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Research 8 , 0682 (2025)

Beyond serving as substrates, KBs and ketogenic diets (KD) may enhance mitochondrial function by promoting mitochondrial biogenesis via NAD-dependent signalling pathways involving SIRT1/2/3, AMPK, PGC-1, and FOXO1/3a, and by increasing mitochondrial respiration through PGC-1mediated effects on respiratory complexes (e.g., complex I/II)

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Our work further implicates Fe-S protein dependent metabolism in the induction of ferroptosis, yet this does not restrict the influence of CHAC1 on other mitochondrial cysteine metabolism that may be relevant to ferroptosis