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Based on these data, we propose the cyclization mechanism represented in Figure 3A , in which the formation of DKP would be dependent on the presence of the amino group in the lateral chain of AX

Moreover, at least 3 other cytoplasmic enzymes including isocitrate dehydrogenase 1 (IDH1), malic enzyme 1 (ME1) and 10-formyltetrahydrofolate dehydrogenase (ALDH1L1) contribute to NADPH synthesis in cytosol

SUb2 recognizes the other (K48-linked) uniquitin molecule and the N-terminal ubiquitin-like domain of ISG15 (refs 74,76 ) (Fig

65 Similarly, a P

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