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Melanin , the pigment responsible for skin coloration, can lead to dark spots and hyperpigmentation when overproduced
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LBPS 01-04 sub chronic toxicity evaluation of polysaccharide peptide ganoderma lucidum in aorta
Available evidence suggests a role for voltage-dependent anion channel (VDAC), located in the OMM, and adenine nucleotide translocase (ANT) across the IMM ( 2 + -induced swelling and MPT, although at a higher threshold, which has been interpreted as evidence against a role for ANT in MPT (Sileikyte et al., 2014)
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