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Recently, belimumab and anifrolumab have shown clinical benefits by neutralizing the B cell activating factor to reduce abnormal B cell survival, and by blocking the type I interferon receptor to inhibit interferon-driven inflammation, improving disease activity, reducing flares, and lowering steroid use (84)

They are generally safer than injections but can cause stomach upset and, rarely, allergic reactions

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Improved Insulin Sensitivity and Lipid Metabolism: Secondary effects of weight loss reduce ectopic fat and systemic inflammation