& Weiler, E
[2] After puncturing the rubber stopper for the first dose, the vial becomes a multi-dose container
For tissue extracts obtained from experiments on Langendorff hearts, the peak shapes and separation were affected by interfering contaminants, so to overcome this we modified the HPLC gradient as described in the Supplementary Table 4, keeping the rest of the parameters unchanged
Figure 6 3.8 CB-839 did not improve cytotoxicity in combination with venetoclax, AZD-5991, and ibrutinib in primary CLL lymphocytes We then tested these drug combinations in the primary CLL cells, both in the native condition ( Figure 7A ) and in media supplemented with cytokines (CD40 ligand and interleukin-4) to mimic the microenvironment and maintain viability ( Figure 7B )
IAM-TPP and IAM- d 15 TPP were reacted with thiosulfate to give the Bunte salts, O 3 SS-CAM-TPP and O 3 SS-CAM-d 15 TPP, and the sulfite was displaced with glutathione to give the glutathione disulfide products, GSS-CAM-TPP and GSS-CAM- d 15 TPP (Supplementary Fig
