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However, not only does p62 prevent NRF2 binding to KEAP1, it induces autophagic degradation of KEAP1, resulting in a positive feedback loop of NRF2 activation [82]

Recent studies also show that -sitosterol suppresses pro-survival signaling cascadesfor instance, an oxidized -sitosterol derivative significantly downregulated phosphorylated ERK1/2 and NF-B p65 levels, leading to increased ceramide accumulation and apoptosis in breast and liver cancer cells (97)

L.JacobsenH.IkemizuS.AnderssonC.HarlosK.MadsenL.et al

* Food Supplements should not be used as a substitute for a varied and balanced diet and healthy lifestyle