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Upon the upregulation and activation of Nrf2, the heterodimers of nuclear Nrf2 and small Maf proteins form to recognize antioxidant response elements (AREs), and then recruit key factors for transcription of Nrf2 target gene including HO-1 (Hayes et al., 2010)

The theoretical advantage is smoother blood levels with less peak-to-trough variation, which may reduce the intensity of side effects, particularly nausea and appetite fluctuation

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By promoting tissue regeneration, reducing inflammation, and stimulating the growth of new blood vessels, BPC-157 helps restore function and alleviate pain

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