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Damaged AECs release pro-inflammatory and pro-fibrotic mediators, including interleukin (IL) -1 and tumor necrosis factor (TNF) -, which promote fibroblast recruitment, inflammatory cell activation (e.g., neutrophils, Th17, gdT cells), and myofibroblast differentiation, ultimately leading to ECM accumulation and fibrotic tissue remodeling [20, 29, 33, 34]

13,14,15 Restoring levels of these in the body can help improve concentration and mental clarity

Dig Dis Sci (2015) 60(8):24706

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Methionine in the form of S-adenosylmethionine (SAM) is required for many methylation reactions, including DNA methylation