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The FTCD gene is located on chromosome 21q22.3 which is composed of 16 exons that generate three alternatively spliced mRNAs, two of which encode the same 541 amino acid protein (isoform A) and the other encodes a protein of 572 amino acids (isoform C)

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That distinction matters for understanding why systemic IGF-1 LR3 administration and local MGF activity are not equivalent in their biological targets, even though both ultimately activate many of the same downstream signalling nodes

As food is a major resource for folate, studies reported that low folate level due to unbalanced diet is associated with higher prevalence on schizophrenia, particularly in infants with maternal nutritional deficiency 11,93