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The PKC pathway becomes activated through hyperglycemia-induced increases in diacylglycerol (DAG), with PKC- and PKC- isoforms particularly implicated in stimulating NOX activity while inhibiting AMPK-mediated antioxidant responses (Geraldes and King, 2018)

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doi: 10.5505/1304.7361.2014.74317 2 AkamatsuY.HanafyK

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