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SOD reduces intracellular superoxide anion levels, thereby mitigating ROS-induced damage [20]

The metformin concentrations for these volunteers were measured in plasma, red blood cells at time points 1, 2, 3, 4, 6, 10, 24 h after oral administration and in urine samples at time points 4, 6, 10, 24 h after oral administration of metformin

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Although positive effects of NAC have been reported for treatments of patients with acute liver failure [61], other studies on acute liver failure and liver surgery suggest patients randomized to postoperative NAC received no benefit [62,63,64]