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However, there are certain limitations that hindered its application in clinical practice

This approach mirrors how anti-obesity medications are used in clinical practice, where long-term maintenance therapy prevents weight regain

Pyruvate kinase (encoding by pykF ) catalyzes phosphoenolpyruvic acid (PEP) to form pyruvate and is a rate-limiting enzyme in the glycolysis pathway

If tirzepatide is already causing significant nausea or headaches , adding phentermine can push side effects past the threshold of tolerability and lead to discontinuation of one or both medications

Because immune-related adverse events were identified through chart review, the evaluation might have been limited by inconsistent documentation of chart notes, such as the underreporting of patient symptoms