In this review, we emphasize on (1) GSH depletion as a fundamental risk factor for diseases like chronic obstructive pulmonary disease and atherosclerosis (ischemic heart disease and stroke), (2) importance of oxidative stress and antioxidants in SARS-CoV-2 infection and COVID-19 disease, (3) significance of GSH to counteract persistent damaging inflammation, inflammaging and early (premature) inflammaging associated with cell and tissue damage caused by excessive oxidative stress and lack of adequate antioxidant defenses in younger individuals, and (4) new therapies that include antioxidant defenses restoration
Anatomical proximity to radiosensitive organs such as the bladder, rectum, and bowel restricts dose escalation and exposes patients to long-term toxicities including fibrosis, necrosis, sexual dysfunction, and urinary or bowel complications [14,15,16]
Safety: Both approaches have associated risks
Importantly, high levels of endogenous total glutathione were always associated with enhanced resistance to TMV
10.1371/journal.pone.0152371 145 JinK.SimpkinsJ
