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Over time, the brain and body can begin to develop a dependence on the substances to maintain normal brain functions. Tolerance for the drug can also develop with continuous use, where a person will need to use more drugs in order to achieve the same effects

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Step 2 Trim Providers With Insufficient CCR Data The next step in our methodology is to remove from the CCR adjustment factor calculation any providers for which we cannot accurately measure changes to their CCR using the PSF data