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Activation of these receptors suppresses nociceptive transmission and alters dopaminergic and stress-response signaling within the central nervous system

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Association of low molecular weight plasma aminothiols with the severity of coronavirus disease-2019

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It does so through an epigenetic mechanism, where FGF15/19 interacts with its target nuclear receptors, such as small heterodimer partner (SHP), which then recruits DNA methyltransferase-3a (DNMT3a) to the lipogenic gene loci, including FASN