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When this stress becomes significant, it can cause degenerative spondylolisthesis (anterior displacement of a vertebral segment) with or without spondylolysis (defect in the pars interarticularis), which can contribute to lumbar spinal stenosis

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They require clinic visits, they cost more, and they don't offer a meaningful advantage over high-dose oral supplementation when absorption isn't the problem

GHK-Cu stimulates blood vessel formation (angiogenesis), nerve outgrowth, and increases synthesis of collagen, elastin, and glycosaminoglycans