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Human Trx and GSH systems have compensatory activities so that inhibition of one arm can be supplemented by the other 60 , suggesting that the inhibition of hTrxR by some of the compounds presented here will not be detrimental for humans as it is for schistosomes

Free radicals are inflammatory substances, which are unstable molecules that are missing an electron

Pediatrics 120, 11831215

The enzyme cytochrome P450, involved in the metabolism of xenobiotics and endogenous compounds, can leak electrons to oxygen during its catalytic cycle, producing superoxide radicals [60]