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doi: 10.3389/fendo.2021.741764 30 BarberTMHansonPWeickertMOFranksS

aureus aggravates AD skin lesions ( Reactive oxygen species are generated in response to different triggers such as allergens, cutaneous dysbiosis, exogenous irritants, pollutants and UV light ( 2 ), nitrate (NO 3 ), and biopyrrin, are significantly increased in AD patients ( To mitigate or avert oxidative damage induced by free radicals, the body has developed an intricate antioxidant defense mechanism

An increase in the levels of 8-hydroxy-2-deoxyguanosine (8-OHdG) and 8-hydroxyguanosine (8OHD), which are primarily localized in A plaques, assesses oxidation in DNA and RNA [44]