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Since 85% of advanced-stage melanoma patients have lung metastases, which is the leading cause of their death, a study was conducted to investigate the potential of intranasal administration of N

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This first-pass mechanism of periportal toxicity for selected compounds, including hepatotoxicants that primarily affect centrilobular hepatocytes, could result from deficient cytoprotective capacity secondary to depletion of phase II conjugating enzymes in addition to being a consequence of a higher exposure gradient to these upstream hepatocytes