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This study aimed to examine the longitudinal trajectory of these symptoms, classify distinct symptom cluster profiles, uncover symptom interconnections, identify core symptoms, and explore associated factors

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To date many studies have reported several miRNAs potentially involved in the modulation of the GH and IGF signaling networks, however, it is still difficult to identify the key players of this complex landscape

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Transcription factor Nrf2 is activated in response to ROS-induced oxidative stress and triggers the expression of its target genes through binding to antioxidant response elements (Ma 2013)