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Synovitisthe swelling of the synovial membraneserves as the front line, where fibroblasts and macrophages swell the ranks, releasing a cytokine storm, in RA, TNF-, IL-6, and harvesting oxidative stress characters all work together as partners in crime to compound and aggravate the situation on the cellular level, as well as at the patient level [5]

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These were searched in scientific databases such as Google Scholar, PubMed, Elsevier/Science Direct, Springer Link, Wiley Online Library, and Taylor & Francis online using various combinations between the following keywords: Vitamin C, cardiovascular diseases, immune system, metabolic disorder, immune modulation, respiratory infections, wound healing, cancer treatment, and antioxidant effect

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The mechanism involves NAD+-dependent enzymes critical for glucose metabolism