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Giredestrant had little impact on the relative abundance of PL species 48 h after treatment

RORt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

Reported side effects include [1][29]: Flatulence Loose stools Skin rash (rare) Flushing (rare) These side effects have generally been mild and self-limiting

This tragedy exposed major gaps in drug safety assessment and led to stricter regulations in clinical research and pharmacovigilance, particularly in post-marketing surveillance

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