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Nguyen TX, Cole AM, Lehrer RI: Evolution of primate -defensins: a serpentine path to a sweet tooth

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CHALLENGES TO DEVELOPMENT In developing the second-generation amylin-analog cagrilintide there were 2 main barriers: (1) to prevent amylin protein aggregation and (2) to extend the amylin-analogs half-life

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Zhang X, Zheng C, Gao Z, Chen H, Li K, Wang L, et al