The risk of hitting a nerve, a major artery, or even injecting directly into the already-damaged tendon (which can cause more trauma) is significant for anyone who isn't an expert in anatomy
The previous study by Gotthardt et al
It reiterated Congressional goals, renamed the initiative the Rapid Innovation Fund (RIF), and directed each Service and Office of the Secretary of Defense Office of the Small Business Program (USD OSBP) to establish RIF award procedures
Safety signals identified through extended follow-up include: Gastrointestinal effects : Nausea, vomiting, and diarrhea remain the most common adverse events, typically diminishing over time but causing discontinuation in approximately 57% of patients Gallbladder disease : Increased incidence of cholelithiasis and cholecystitis, possibly associated with weight loss, though the exact mechanism remains under investigation Diabetic retinopathy : Risk of complications, particularly with rapid glycemic improvement in patients with pre-existing retinopathy Acute kidney injury : Risk associated with severe gastrointestinal adverse events leading to dehydration Pancreatitis : Rare cases reported, though causality remains uncertain
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