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In the AMY 1 R and AMY 3 R Y37 rAmy interacts with residues in the respective RAMP and the CTR ECD, however the small side chain of P37 Cagri is completely buried by the surrounding CTR ECD residues, forming extensive hydrophobic contacts with W79 ECD and no direct interactions with either RAMP1 (AMY 1 R) or RAMP3 (AMY 3 R), again consistent with the restrictive interactions formed by Pro32 sCT with the CTR ECD
In the end, the excess hydrogen peroxide wins out and discolors your hair, turning it gray or, if the intense stress persists, eventually white
Route differences introduce pharmacokinetic variables (Tmax, Cmax, AUC) that make direct efficacy comparisons unreliable
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Ineffective erythropoiesis in -thalassemia
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